MonsterCare is a management-simulation game, in which the player oversees a shelter for neglected and homeless monsters. Starting from a single room in the attic and a one lost monster, the player develops their shelter into an expansive operation, housing multiple monsters with different traits, needs and abilities.

As monsters arrive to the shelter, the player is tasked with maintaining their health, happiness and general well-being, and training them in different disciplines. In order for the monsters to "graduate", the player needs to fill adoption contracts, which have specific requirements regarding the monster's qualities: breed, attributes, and training.

After completing adoption contracts, the player is rewarded with money and experience points, which can be spent on expanding and improving the shelter: customizing rooms, unlocking new capabilities, automating tasks etc.