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In Pathogenic, you are the disease.

Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and completely conquer your human host.

To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction, creating powerful, game-breaking builds to become the ultimate pathogen.

CREATE YOUR OWN PATHOGEN

Loot, graft, and assemble your parasite from dozens of unique organelles. Combine lashes for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Discover powerful synergies to build an unstoppable disease.

FIGHT THE IMMUNE SYSTEM

Battle a diverse roster of enemies, from basic immune cells like macrophages and T-cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host's organs.

EXPLORE A MICROSCOPIC WORLD

Navigate the human body, a procedurally generated world of organic wonder. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.

FEEL THE ORGANIC ACTION

Our detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures that no two runs are ever the same, offering endless, challenging gameplay that always stays fresh.

Pathogenic
Aberrant LabsDeveloper
Aberrant LabsPublisher
Coming soonRelease
🎹🖱️ Keyboard + Mouse
🕹️ Partial Controller Support
🎮 Full Controller Support
No user reviews (0 reviews)
Biweekly Update 01 - More Firepower

Hi everyone,

Pathogenic\'s Demo will be getting a new patch every two weeks, starting with a bunch of new content today! In this update, we are bringing you new weapons, organelles, a new enemy and a range of rebalancing, optimizations and fixes.

New Weapons and Organelles

[carousel][img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/fe70b68e35674017f87e3c32dacd2991b65e9645.png\"][/img][img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/116cb090bdd32fdfc6c08f737877df5bf8adf56f.png\"][/img][img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/555a1e0cc3a230538568db5003f292ec970bd767.png\"][/img][/carousel]

3 new weapons have been added to your arsenal. Your pathogen now has more firepower than ever before! (Try not to get hit by your own explosions though.)

  • Dehiscence Lobber: powerful bombs with a risk of friendly fire.

    [/*]
  • Cnidocyst: ties down target with a thread

    [/*]
  • Rotary Extruder: bullets go brrrrr when overcharged

    [/*]

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/282734264e9115568db72db558d9b8559aee6b06.gif\"][/img]

11 new internal organelles have also been added for more interesting synergies in your build combos.

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/05302d0b759daab564d9df4aa090a9b077418b5a.png\"][/img]

New Enemy

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/42f4bed6e4208cf0577d5a4a27b0dfa7d894b013.jpg\"][/img]

The Wave Macrophage joins the battle, mostly appearing in the Stomach area. It has a wide AOE attack and can be dangerous in tight spaces.

Patch Notes

Aside from new content, I\'ve also been working on improving Pathogenic\'s gameplay with UI and visual updates, as well as balancing changes. See below for the full patch notes.

Content

New Weapons

  • Dehiscence Lobber

    [/*]
  • Rotary Extruder

    [/*]
  • Cnidocyst

    [/*]

New Internal Organelles

  • Magnetosome

    [/*]
  • Vesicle

    [/*]
  • Iridophore Membrane

    [/*]
  • Sympathetic Detonator

    [/*]
  • Refiner

    [/*]
  • Resonant Cavity

    [/*]
  • Turgosome

    [/*]
  • Phagosome

    [/*]
  • Starved Oxysome

    [/*]
  • Autophagic Mitochondrion

    [/*]
  • Endospore

    [/*]

New Enemy

  • Wave Macrophage

    [/*]

Balance and Gameplay

  • Chronosome now works with melee attacks

    [/*]
  • Reduced explosion scaling on Blastocyst Mortar

    [/*]
  • Slightly reduced max HP of The Wall and The Rock

    [/*]
  • Slightly reduced enemy HP scaling for each organ

    [/*]
  • Nerfed a couple of very hard rooms in the liver

    [/*]
  • Enemy bullets now disappear after beating the boss

    [/*]
  • Toxins disappear after finishing a room with Toxin Spreaders

    [/*]
  • Plasmid fragments are now attracted to you

    [/*]
  • Rooms spawning next to the start rooms are now even easier

    [/*]

Optimizations

  • Added control remapping and input icons matching the connected controller type

    [/*]
  • Added controller rumble

    [/*]
  • Improved Helmith jank, it should no longer tangle in itself and get stuck in walls

    [/*]
  • Added a screen transition animation

    [/*]
  • Significantly optimized level generation loading times

    [/*]
  • Graphics and physics optimizations

    [/*]
  • More graphics options

    [/*]

Visual improvements

  • Improved the distortion of the cells in walls

    [/*]
  • Added normal maps to special room hallway props

    [/*]
  • Added more vein props to rooms

    [/*]
  • Updated UI for the fast travel prompt

    [/*]

Localization

  • Russian and Finnish translations now available

    [/*]

[ 2025-11-20 17:40:20 CET ] [Original Post]

Minimum Setup

  • Graphics: GTX 1050
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