In Pathogenic, you are the disease.
Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and completely conquer your human host.
To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction, creating powerful, game-breaking builds to become the ultimate pathogen.
CREATE YOUR OWN PATHOGEN
Loot, graft, and assemble your parasite from dozens of unique organelles. Combine lashes for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Discover powerful synergies to build an unstoppable disease.
FIGHT THE IMMUNE SYSTEM
Battle a diverse roster of enemies, from basic immune cells like macrophages and T-cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host's organs.
EXPLORE A MICROSCOPIC WORLD
Navigate the human body, a procedurally generated world of organic wonder. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.
FEEL THE ORGANIC ACTION
Our detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures that no two runs are ever the same, offering endless, challenging gameplay that always stays fresh.
Welcome back everyone!
Its been two weeks, so time for a shocking update! Were back with a fresh batch of brand-new content, as well as a plethora of changes to gameplay, balancing and UI.
New Weapons and Organelles
This update contains both new weapons and new internal organelles. Check out all the new toys!
Weapons
\n[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/5d41d331fd429b1e133dc86f87b9c6fb26962d6e.gif\"][/img]
Galvanic Conduit: Zap foes with electric discharge (UNLIMITED POWERRRR!! ...actually, limited by your stamina)
[/*]
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/c8751c13fca76e2b993a32cff341a2999fbad3a3.gif\"][/img]
Conductive Cnidocyst: Sharing is caring. Bind your enemies together and make them share all damage taken.
[/*]
Internal Organelles
Galvanic Sac: Automatically discharges energy to nearby enemies
[/*]
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/72ca9b006409a9ddc553ce7ae24e3e50e5577404.jpg\"][/img]
Sentry Polyp: Spawns turrets for more firepower (and perhaps meat shields too
[/*]
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/4d8d251e7b41cc84dd0225aeb3c51894a2f9bce3.jpg\"][/img]
Golgi Apparatus: Transfers connected melee attacks to connected projectile attacks (essentially, your projectiles can deliver melee strikes)
[/*]
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/0a62900daeafa0854b5a5801c6ecd35395e1f589.jpg\"][/img]
Dorasal Lysosome: Become an assassin with the backstab damage boost
[/*]Crytobiotic Core: An explosive second chance for your pathogen to fight on
[/*]Resilinoplast: Reflect projectiles with your own attacks
[/*]
Loot Changes
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/5cae6e4a0d04dc3ea144877d288a9516b134df2b.png\"][/img]
You can now find Cursed Chests floating around different organs. They contain random rewards, for a price. Do you feel lucky today?
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/4bc1fa7b34bd7475f0ead2106359ee7e91d81ac3.jpg\"][/img]
Special rooms now also require an upfront payment before opening their doors. Gone are the days of walking straight in and looting everything clean. Be careful with how much you spend You dont know when youll need some spare cash!
Organelle Visuals Rework
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/1144aa1bd837615ebeb0cf72dadb8204617dd267.jpg\"][/img]
We want your parasite to appear more visually distinct as it takes on different organelles to really show off the unique evolution progress. Thats why in this patch, weve reworked the backgrounds of the internal organelles so they can influence the look of your pathogen even more.
Music
Pathogenics soundtracks have always been integral to the combat experience. In this patch weve made them cleaner, longer, and now your cellular combat action is ever more hyped. It\'s a pity we can\'t put audio files in this blog, so do load up the demo and listen to the music yourself!
UI Updates
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/17c0547fa1ed5b610ae0a1c08ce0bdf0c2fe5a7e.jpg\"][/img]
Weve received requests from many players who want to take a closer look at their parasites. So heres the Photo Mode, where you can pause the game and zoom in on your pathogen.
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/4e17c86298d18d58f1d76d2ef39f4c04f28bdd3f.jpg\"][/img]
Great news for speedrunners: Pathogenic now has a page on speedrun.com ! And to help you time your runs, a new Speedrun Timer has been added to gameplay settings.
Patch Notes
Aside from what was mentioned above, the update also contains a myriad of other changes in gameplay, optimizations and visuals. See below for the full details:
New Organelles
Weapons
Galvanic Conduit
[/*]Conductive Cnidocyst
[/*]
Internal Organelles
Golgi Apparatus
[/*]Sentry Polyp
[/*]Galvanic Sac
[/*]Dorasal Lysosome
[/*]Cryptobiotic Core
[/*]Resilinoplast
[/*]
Gameplay
Cursed chests appear
[/*]Special rooms now require payment to access them
[/*]DNA now drops after killing enemies instead of finishing a room
[/*]Improved Cnidocyst jankiness
[/*]Toxic flagellum no longer deals damage to unangered shopkeeper
[/*]Overcharge indicator showing the accumulated energy on some organelles
[/*]
Balance
(Unless otherwise mentioned, all stats refer to organelles\' basic rarity)
Rework on how the organelle chaining works. Now cycles of organelles can no longer repeat and apply at most once. Sounds like a small change but some cycle builds that went out of control before are now significantly nerfed. Also these cycles should no longer crash your game
[/*]
Buffs
Magnetosome: attracted projectiles now pierce enemies and lifetime extended
[/*]Vengeful Mitochondria: Overcharge time extended (5 seconds -> 7 seconds)
[/*]
Nerfs
Recuperative Mitochondria: Now only gets charged from connected attacks. Provides 50% less charge
[/*]Sympathetic Detonator: Reduced splash damage (150% -> 120%)
[/*]Pressurized Spicule: Reduced damage (60 dps -> 56 dps)
[/*]Rotary Extruder: Reduced damage (225 dps -> 200 dps)
[/*]
Visuals
Added Environment Quality: Mid and Postprocessing Quality: Mid level for a good balance between performance and looks
[/*]Internal organelle visuals rework with backgrounds to influence the look of your parasite more
[/*]
Audio
Updated music for skin and stomach, tracks cleaned up and extended
[/*]
UI
Photo mode on P to get your perfect screenshot
[/*]Setting to hide damage numbers and disable pausing on lost focus
[/*]Speedrunning timer added
[/*]
Optimizations
Better detection of borked physics state that previously led to crashes
[/*]
Minimum Setup
- Graphics: GTX 1050
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