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In Pathogenic, you are the disease.

Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and completely conquer your human host.

To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction, creating powerful, game-breaking builds to become the ultimate pathogen.

CREATE YOUR OWN PATHOGEN

Loot, graft, and assemble your parasite from dozens of unique organelles. Combine lashes for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Discover powerful synergies to build an unstoppable disease.

FIGHT THE IMMUNE SYSTEM

Battle a diverse roster of enemies, from basic immune cells like macrophages and T-cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host's organs.

EXPLORE A MICROSCOPIC WORLD

Navigate the human body, a procedurally generated world of organic wonder. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.

FEEL THE ORGANIC ACTION

Our detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures that no two runs are ever the same, offering endless, challenging gameplay that always stays fresh.

Pathogenic
Aberrant LabsDeveloper
Aberrant LabsPublisher
Coming soonRelease
🎹🖱️ Keyboard + Mouse
🕹️ Partial Controller Support
🎮 Full Controller Support
No user reviews (0 reviews)
Biweekly Update 03 - The Swarm

Greetings, fellow parasites!

We have a Christmas gift for you! It\'s been two weeks and you know the drill: time for a biweekly update. This week we are bringing in a whole new playstyle summoning. Tired of getting outnumbered all the time? With the new weapon and organelles, you can become the swarm yourself.

New Weapon and Organelles

This batch of new toys features an array of auto-attacking tools - let your minions do all the fighting for you!

Weapon

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/3845b6a31cb676243ed5f2b47b3876d3a1e16695.gif\"][/img]

  • Nidublast: Throw an army at your problems with this new gun that spawns minion

    [/*]

Internal Organelles

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/d86f971544bec45dafdcb2c1036017c32dae350d.jpg\"][/img]

  • Swarm Nidus: Spawns weak and fast shooting minions to overwhelm with numbers

    [/*]

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/7d076864caf9d68b0620d1e46d0304ce09ecec94.jpg\"][/img]

  • Apex Nidus: Spawns one strong melee minion quality over quantity

    [/*]

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/31597cc9415598ff3078dba08ffaf4fc7c2c9481.jpg\"][/img]

  • Galvanic Weave: A net of lightning! Attacks connect to each other with an electric arc

    [/*]

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/7f835d39c4944d497d8590c196f31cedb94b3989.jpg\"][/img]

  • Toxisome: Chemical warfare with your attacks leaving behind a toxic trail.

    [/*]
  • Necrolytic Igniter: Triggers explosions with enemy gibs. Even dead enemies can be useful!

    [/*]
  • Galvanic Infuser: Electricfy your attacks and make them arc towards nearby enemies.

    [/*]
  • Sinoatrial Node: Do you like rhythm games? Boost your damage when hitting on the beat of the music.

    [/*]
  • Elusive Mitochondrion: provides overcharge as you dodge and weave through enemy projectiles

    [/*]
  • Metabolic Mitochondrion: picking up loot doesnt just give your resources it gives you overcharge too!

    [/*]
  • Vacuole: Stores overcharge so you can save it for later. Activate to release the charges, when you need a little extra oomph

    [/*]

Specialized Skill Trees

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/f461870213c80879302c34b81022fface07feded.jpg\"][/img]

We want you to have even more flexibility in your gameplay, so we gave each type of pathogen their own plasmid skill tree. You can now customize your playstyles specific to the pathogen of your choice!

Holiday Bonus

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/bfad3cd442bc7eff5eb370c65694efbb96d09e83.jpg\"][/img]

Christmas is coming and the human host is celebrating. Even the immune cells are feeling festive with their new hats! (We\'re crashing their party though.)

Teaser

Before we go into the patch notes, heres a little teaser of what Roberto, Pathogenics amazing artist, has been working on. He\'s been the mastermind behind the art of Pathogenic\'s levels, organelles and all organisms, and theres so much he has in store for you all.

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/fdb1353a896b8a7ec28df521cebef21a8203a9ba.jpg\"][/img]A sneak peek at the intestine, a labyrinth of danger awaiting your pathogens arrival.

[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/48af94fe2fbdf8f6796da3340dbae510c44f9c03.jpg\"][/img]The editor looking a little different, doesnt it?

Full Patch Notes

Aside from the new content, this patch also introduces a myriad of rebalancing, UI adjustments and visual improvements. See the full details below:

Content

Weapon

  • Nidublast

    [/*]

Organelle

  • Swarm Nidus

    [/*]
  • Apex Nidus

    [/*]
  • Sinoatrial Node

    [/*]
  • Galvanic Weave

    [/*]
  • Elusive Mitochondrion

    [/*]
  • Metabolic Mitochondrion

    [/*]
  • Vacuole

    [/*]
  • Necrolytic Igniter

    [/*]
  • Galvanic Infuser

    [/*]
  • Toxisome

    [/*]

Metaprogression

  • New plasmid skill trees for the Helminth and the Fungal Spore

    [/*]
  • Moved specialized plasmids for Bacteria to the sides of the tree

    [/*]

Gameplay

  • Make cursed chest payouts chances for better rewards higher

    [/*]
  • Remove recuperative mitochondria from starting pool

    [/*]
  • Shops now sometimes have a reroll machine

    [/*]
  • Range and overcharge strength upgrades are now additive instead of multiplicative

    [/*]
  • Improve beam thickness scaling with damage

    [/*]
  • Improve lightning beam homing

    [/*]
  • Very slightly buff the rock and the wall boss

    [/*]
  • Fix broken chronosome overcharge that didn\'t do anything before

    [/*]

Balance

  • Increase scaling of DNA needed to level up to 3

    [/*]
  • Increase Golgi Apparatus base damage from -30% to -10%

    [/*]
  • Golgi Apparatus now also triggers on missed hits

    [/*]
  • Increase Sentry Polyp\'s i-frames from 0.8s to 1.2s

    [/*]
  • Reduce sympathetic detonator base damage from 120% to 100%

    [/*]
  • Reworked Toxic Flagellum to deal damage every 0.5 seconds

    [/*]

UI

  • Updated DNA bar

    [/*]
  • Moved UI to the bottom left

    [/*]
  • Actives can now be bound to the secondary fire button

    [/*]
  • Added UI hint for aiming with the controller

    [/*]

Visuals

  • Added glowing veins and other props to most rooms

    [/*]
  • Lashes now have colors based on rarity

    [/*]
  • Updated image for Cnidocyst, Galvanic Conduit, Resilinoplast bubble

    [/*]
  • Added Santa hats

    [/*]

Music

  • Cleanup stomach fight music

    [/*]

And that wraps up the third and final biweekly update of this year. Hope you all like the new toys and have fun with it during the holidays. Also, thank you for making 2025 such an amazing year for us we can\'t ask for a better community and demo launch. It\'s been a great pleasure seeing everyone enjoying the game. If you have any new ideas and feedback for us, join us on Discord and let us know what you think! We\'ll be back with more updates in 2026. In the mean while, merry Christmas and have a happy New Year!

[ 2025-12-18 16:18:47 CET ] [Original Post]

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  • Graphics: GTX 1050
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